Shapeshifting volcano virus points to new ways to deliver medicine, vaccines

Journal Reference: Fengbin Wang, Virginija Cvirkaite-Krupovic, Matthijn Vos, Leticia C. Beltran, Mark A.B. Kreutzberger, Jean-Marie Winter, Zhangli Su, Jun Liu, Stefan Schouten, Mart Krupovic, Edward H. Egelman. Spindle-shaped archaeal viruses evolved from rod-shaped ancestors to package a larger genome. Cell, 2022; DOI: 10.1016/j.cell.2022.02.019 While the vast majority of viruses are either rod-like or spherical (such … Read more

New way to deliver DNA-based therapies for diseases

Journal Reference: Craig Van Bruggen, David Punihaole, Allison R. Keith, Andrew J. Schmitz, Jakub Tolar, Renee R. Frontiera, Theresa M. Reineke. Quinine copolymer reporters promote efficient intracellular DNA delivery and illuminate a protein-induced unpackaging mechanism. Proceedings of the National Academy of Sciences, 2020; 202016860 DOI: 10.1073/pnas.2016860117 The research is published in the Proceedings of the … Read more