From cavefish to people: Evolution of metabolism in cavefish may provide insight into treatments for a host of diseases such as diabetes, heart illness, and stroke

From cavefish to people: Evolution of metabolism in cavefish may provide insight into treatments for a host of diseases such as diabetes, heart illness, and stroke – NovLink Home Mash G From cavefish to people: Evolution of metabolism in cavefish may provide insight into treatments for a host of diseases such as diabetes, heart illness, … Read more

New information about amyloid filaments in neurodegenerative diseases

Journal Reference: Manuel Schweighauser, Diana Arseni, Mehtap Bacioglu, Melissa Huang, Sofia Lövestam, Yang Shi, Yang Yang, Wenjuan Zhang, Abhay Kotecha, Holly J. Garringer, Ruben Vidal, Grace I. Hallinan, Kathy L. Newell, Airi Tarutani, Shigeo Murayama, Masayuki Miyazaki, Yuko Saito, Mari Yoshida, Kazuko Hasegawa, Tammaryn Lashley, Tamas Revesz, Gabor G. Kovacs, John van Swieten, Masaki Takao, … Read more

Once called cellular particles, tiny bubbles may play key role in understanding, treating diseases

Journal Reference: Inna A. Nikonorova, Juan Wang, Alexander L. Cope, Peter E. Tilton, Kaiden M. Power, Jonathon D. Walsh, Jyothi S. Akella, Amber R. Krauchunas, Premal Shah, Maureen M. Barr. Isolation, profiling, and tracking of extracellular vesicle cargo in Caenorhabditis elegans. Current Biology, 2022; DOI: 10.1016/j.cub.2022.03.005 The study, which appears in the journal Current Biology, … Read more

Single test for over 50 genetic diseases will cut diagnosis from decades to days

Journal Reference: Igor Stevanovski, Sanjog R. Chintalaphani, Hasindu Gamaarachchi, James M. Ferguson, Sandy S. Pineda, Carolin K. Scriba, Michel Tchan, Victor Fung, Karl Ng, Andrea Cortese, Henry Houlden, Carol Dobson-Stone, Lauren Fitzpatrick, Glenda Halliday, Gianina Ravenscroft, Mark R. Davis, Nigel G. Laing, Avi Fellner, Marina Kennerson, Kishore R. Kumar, Ira W. Deveson. Comprehensive genetic diagnosis … Read more

Possible common thread between many neurodegenerative diseases

Journal Reference: Andrew Chang, Xinyu Xiang, Jing Wang, Carolyn Lee, Tamta Arakhamia, Marija Simjanoska, Chi Wang, Yari Carlomagno, Guoan Zhang, Shikhar Dhingra, Manon Thierry, Jolien Perneel, Bavo Heeman, Lauren M. Forgrave, Michael DeTure, Mari L. DeMarco, Casey N. Cook, Rosa Rademakers, Dennis W. Dickson, Leonard Petrucelli, Michael H.B. Stowell, Ian R.A. Mackenzie, Anthony W.P. Fitzpatrick. … Read more

African ‘hotspot’ for highly infectious diseases

Journal Reference: Kefyalew Addis Alene, Ahmed Elagali, Dylan D Barth, Susan F Rumisha, Punam Amratia, Daniel J Weiss, Kendalem Asmare Atalell, Andargachew Kumsa Erena, Peter W Gething, Archie C A Clements. Spatial codistribution of HIV, tuberculosis and malaria in Ethiopia. BMJ Global Health, 2022; 7 (2): e007599 DOI: 10.1136/bmjgh-2021-007599 The new research, published today in … Read more

Researchers identify potential new means of slowing neurodegenerative diseases

Journal Reference: Megan Jandy, Asra Noor, Pascal Nelson, Cassandra N. Dennys, Isabella M. Karabinas, Jeanine C. Pestoni, Gautam D. Singh, Lam Luc, Rachel Devyldere, Nathalie Perdomo, Catherine E. Mitchell, Levi Adams, Marisa A. Fuse, Francine A. Mendoza, Carrie L. Marean-Reardon, Ryan A. Mehl, Alvaro G. Estevez, Maria Clara Franco. Peroxynitrite nitration of Tyr 56 in … Read more

Easy, cheap, fast and accurate nano-sensors pinpoint infectious diseases

Journal Reference: Xiahui Chen, Shoukai Kang, Md Ashif Ikbal, Zhi Zhao, Yuxin Pan, Jiawei Zuo, Liangcai Gu, Chao Wang. Synthetic nanobody-functionalized nanoparticles for accelerated development of rapid, accessible detection of viral antigens. Biosensors and Bioelectronics, 2022; 202: 113971 DOI: 10.1016/j.bios.2022.113971 In a new study, Chao Wang, a researcher at Arizona State University’s Biodesign Institute and … Read more

How brain cells die in prion diseases

Journal Reference: Romain Chassefeyre, Tai Chaiamarit, Adriaan Verhelle, Sammy Weiser Novak, Leonardo R. Andrade, André D. G. Leitão, Uri Manor, Sandra E. Encalada. Endosomal sorting drives the formation of axonal prion protein endoggresomes. Science Advances, 2021; 7 (52) DOI: 10.1126/sciadv.abg3693 The accumulation of protein aggregates in axons, along with axonal swellings and other signs of … Read more

New way to deliver DNA-based therapies for diseases

Journal Reference: Craig Van Bruggen, David Punihaole, Allison R. Keith, Andrew J. Schmitz, Jakub Tolar, Renee R. Frontiera, Theresa M. Reineke. Quinine copolymer reporters promote efficient intracellular DNA delivery and illuminate a protein-induced unpackaging mechanism. Proceedings of the National Academy of Sciences, 2020; 202016860 DOI: 10.1073/pnas.2016860117 The research is published in the Proceedings of the … Read more