Novel preclinical drug could have potential to combat melancholy, brain injury and cognitive disorders

Journal Reference: Alan Umfress, Sarbjit Singh, Kevin J. Ryan, Ayanabha Chakraborti, Florian Plattner, Yogesh Sonawane, Jayapal Reddy Mallareddy, Edward P. Acosta, Amarnath Natarajan, James A. Bibb. Systemic Administration of a Brain Permeable Cdk5 Inhibitor Alters Neurobehavior. Frontiers in Pharmacology, 2022; 13 DOI: 10.3389/fphar.2022.863762 Cdk5 is a crucial regulator of signaling in brain neurons. Over three … Read more

Johnny Depp’s Ex Suffering From Two Personality Disorders? Actress’ Cross-Examination Next Week Will Reportedly Be The ‘Most Telling’

Johnny Depps Ex Suffering From Two Personality Disorders Actress Cross

The ongoing court battle between Amber Heard and Johnny Depp had become a parade of disturbing details from their relationship, which ended when the Aquaman actress filed for divorce in 2016. Amber also obtained a domestic violence restraining order against Johnny at the time, accusing the Pirates of the Caribbean star of physically and verbally … Read more

Good information: People can recover and thrive after mental illness and substance-use disorders

Journal Reference: Andrew R. Devendorf, Ruba Rum, Todd B. Kashdan, Jonathan Rottenberg. Optimal Well-Being After Psychopathology: Prevalence and Correlates. Clinical Psychological Science, 2022; 216770262210788 DOI: 10.1177/21677026221078872 “Our research tells us how many people can recover from a mental illness and go on to experience a life with high levels of well-being and functioning,” said Andrew … Read more

Improving the targeted treatment of movement disorders

Journal Reference: Andreas Horn, Martin M. Reich, Siobhan Ewert, Ningfei Li, Bassam Al-Fatly, Florian Lange, Jonas Roothans, Simon Oxenford, Isabel Horn, Steffen Paschen, Joachim Runge, Fritz Wodarg, Karsten Witt, Robert C. Nickl, Matthias Wittstock, Gerd-Helge Schneider, Philipp Mahlknecht, Werner Poewe, Wilhelm Eisner, Ann-Kristin Helmers, Cordula Matthies, Joachim K. Krauss, Günther Deuschl, Jens Volkmann, Andrea A. … Read more

Antabuse may help revive vision in people with progressive blinding disorders

Journal Reference: Michael Telias, Kevin K. Sit, Daniel Frozenfar, Benjamin Smith, Arjit Misra, Michael J. Goard and Richard H. Kramer. Retinoic acid inhibitors mitigate vision loss in a mouse model of retinal degeneration. Science Advances, 2022 DOI: 10.1126/sciadv.abm4643 The drug may revive sight in humans with the inherited disease retinitis pigmentosa (RP), and perhaps in … Read more

Communication defect in psychotic disorders

Journal Reference: Valentina Mancini, Vincent Rochas, Martin Seeber, Nicolas Roehri, Tonia A. Rihs, Victor Ferat, Maude Schneider, Peter J. Uhlhaas, Stephan Eliez, Christoph M. Michel. Aberrant Developmental Patterns of Gamma-Band Response and Long-Range Communication Disruption in Youths With 22q11.2 Deletion Syndrome. American Journal of Psychiatry, 2022; 179 (3): 204 DOI: 10.1176/appi.ajp.2021.21020190 In the mammalian brain, … Read more

Scientists discover a new molecular pathway shared by two neurodegenerative disorders

Journal References: Anna-Leigh Brown, Oscar G. Wilkins, Matthew J. Keuss, Sarah E. Hill, Matteo Zanovello, Weaverly Colleen Lee, Alexander Bampton, Flora C. Y. Lee, Laura Masino, Yue A. Qi, Sam Bryce-Smith, Ariana Gatt, Martina Hallegger, Delphine Fagegaltier, Hemali Phatnani, Hemali Phatnani, Justin Kwan, Dhruv Sareen, James R. Broach, Zachary Simmons, Ximena Arcila-Londono, Edward B. Lee, … Read more

Eating disorders linked to diabetic eye issues

Journal Reference: Mike Trott, R. Driscoll, E. Iraldo, S. Pardhan. Pathological eating behaviours and risk of retinopathy in diabetes: a systematic review and meta-analysis. Journal of Diabetes & Metabolic Disorders, 2022; DOI: 10.1007/s40200-022-00980-x Diabetes is characterised by high concentrations of glucose in the blood, which can in turn lead to tissue damage in several parts … Read more

Study reveals likely link between mitochondrial dysfunction and age-dependent cognitive disorders

Study reveals likely link between mitochondrial dysfunction and age-dependent cognitive disorders – NovLink Home Mash I Study reveals likely link between mitochondrial dysfunction and age-dependent cognitive disorders We would like to say thanks to the writer of this article for this amazing web content Study reveals likely link between mitochondrial dysfunction and age-dependent cognitive disorders

Study shows brain differences in interpreting physical signals in mental health disorders

Journal Reference: Camilla L. Nord, Rebecca P. Lawson, Tim Dalgleish. Disrupted Dorsal Mid-Insula Activation During Interoception Across Psychiatric Disorders. American Journal of Psychiatry, 2021; appi.ajp.2020.2 DOI: 10.1176/appi.ajp.2020.20091340 The researchers, from the University of Cambridge, found that the part of the brain which interprets physical signals from the body behaves differently in people with a range … Read more