Bioprinting for bone repair improved with genes

Journal Reference: Kazim K. Moncal, R. Seda Tigli Aydın, Kevin P. Godzik, Timothy M. Acri, Dong N. Heo, Elias Rizk, Hwabok Wee, Gregory S. Lewis, Aliasger K. Salem, Ibrahim T. Ozbolat. Controlled Co-delivery of pPDGF-B and pBMP-2 from intraoperatively bioprinted bone constructs improves the repair of calvarial defects in rats. Biomaterials, 2022; 281: 121333 DOI: … Read more

Landmark study implicates specific genes in schizophrenia

Journal Reference: Vassily Trubetskoy et al. Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Nature, 2022; DOI: 10.1038/s41586-022-04434-5 A group of hundreds of researchers across 45 countries analysed DNA from 76,755 people with schizophrenia and 243,649 without it to better understand the genes and biological processes underpinning the condition. The Psychiatric Genomics Consortium … Read more

The role of genes in prenatal responses to air pollution

Journal Reference: Carmen H. Lau, Drew Pendleton, Nicholas L. Drury, Jiayun Zhao, Yixin Li, Renyi Zhang, Gus A. Wright, Aline Rodrigues Hoffmann, Natalie M. Johnson. NRF2 Protects against Altered Pulmonary T Cell Differentiation in Neonates Following In Utero Ultrafine Particulate Matter Exposure. Antioxidants, 2022; 11 (2): 202 DOI: 10.3390/antiox11020202 In a study published in the … Read more

DNA discovery reveals a critical ‘accordion impact’ for switching off genes

Journal Reference: Andrew Keniry, Natasha Jansz, Linden J. Gearing, Iromi Wanigasuriya, Joseph Chen, Christian M. Nefzger, Peter F. Hickey, Quentin Gouil, Joy Liu, Kelsey A. Breslin, Megan Iminitoff, Tamara Beck, Andres Tapia del Fierro, Lachlan Whitehead, Andrew Jarratt, Sarah A. Kinkel, Phillippa C. Taberlay, Tracy Willson, Miha Pakusch, Matthew E. Ritchie, Douglas J. Hilton, Jose … Read more

Appetite genes control how children grow

Journal Reference: Øyvind Helgeland, Marc Vaudel, Pol Sole-Navais, Christopher Flatley, Julius Juodakis, Jonas Bacelis, Ingvild L. Koløen, Gun Peggy Knudsen, Bente B. Johansson, Per Magnus, Ted Reichborn Kjennerud, Petur B. Juliusson, Camilla Stoltenberg, Oddgeir L. Holmen, Ole A. Andreassen, Bo Jacobsson, Pål R. Njølstad, Stefan Johansson. Characterization of the genetic architecture of infant and early … Read more

Study connects shorter course of antibiotics to fewer antibiotic resistance genes

Journal Reference: M. M. Pettigrew, J. Kwon, J. F. Gent, Y. Kong, M. Wade, D. J. Williams, C. B. Creech, S. Evans, Q. Pan, E. B. Walter, J. M. Martin, J. S. Gerber, J. G. Newland, M. E. Hofto, M. A. Staat, V. G. Fowler, H. F. Chambers, W. C. Huskins. Comparison of the Respiratory … Read more

Bacteria genes gave ancient plants traits to colonize land

Journal Reference: Jianchao Ma, Shuanghua Wang, Xiaojing Zhu, Guiling Sun, Guanxiao Chang, Linhong Li, Xiangyang Hu, Shouzhou Zhang, Yun Zhou, Chun-Peng Song, Jinling Huang. Major episodes of horizontal gene transfer drove the evolution of land plants. Molecular Plant, 2022; DOI: 10.1016/j.molp.2022.02.001 “Our study changes the conventional view on land-plant evolution,” says senior author Jinling Huang, … Read more

How a two-faced molecule can silence problematic genes

Journal Reference: Masaki Ohyagi, Tetsuya Nagata, Kensuke Ihara, Kie Yoshida-Tanaka, Rieko Nishi, Haruka Miyata, Aya Abe, Yo Mabuchi, Chihiro Akazawa, Takanori Yokota. DNA/RNA heteroduplex oligonucleotide technology for regulating lymphocytes in vivo. Nature Communications, 2021; 12 (1) DOI: 10.1038/s41467-021-26902-8 Gene expression is at the root of controlling cellular activity. Disease can result when certain genes are … Read more

How well do boosters work? Depends on your genes

Journal Reference: Melissa M. Lemke, Robert M. Theisen, Emily R. Bozich, Milla R. McLean, Christina Y. Lee, Ester Lopez, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayaphan, Sven Kratochvil, Bruce D. Wines, P. Mark Hogarth, Stephen J. Kent, Amy W. Chung, Kelly B. Arnold. A Quantitative Approach to Unravel the Role of Host Genetics in IgG-FcγR Complex … Read more

Machine learning uncovers ‘genes of significance’ in agriculture and medicine

Journal Reference: Cheng, CY., Li, Y., Varala, K. et al. Evolutionarily informed machine learning enhances the power of predictive gene-to-phenotype relationships. Nat Commun, 2021 DOI: 10.1038/s41467-021-25893-w Using genomic data to predict outcomes in agriculture and medicine is both a promise and challenge for systems biology. Researchers have been working to determine how to best use … Read more