From cavefish to people: Evolution of metabolism in cavefish may provide insight into treatments for a host of diseases such as diabetes, heart illness, and stroke

From cavefish to people: Evolution of metabolism in cavefish may provide insight into treatments for a host of diseases such as diabetes, heart illness, and stroke – NovLink Home Mash G From cavefish to people: Evolution of metabolism in cavefish may provide insight into treatments for a host of diseases such as diabetes, heart illness, … Read more

Stroke treatments safe and effective for people with existing disability or dementia, study suggests

Journal Reference: Aravind Ganesh, Justin F. Fraser, Gillian L. Gordon Perue, Sepideh Amin-Hanjani, Thabele M. Leslie-Mazwi, Steven M. Greenberg, Philippe Couillard, Negar Asdaghi, Mayank Goyal. Endovascular Treatment and Thrombolysis for Acute Ischemic Stroke in Patients With Premorbid Disability or Dementia: A Scientific Statement From the American Heart Association/American Stroke Association. Stroke, 2022; DOI: 10.1161/STR.0000000000000406 The … Read more

Pioneering technique could unlock targeted treatments for cancer

Journal Reference: Joshua P. Smalley, India M. Baker, Wiktoria A. Pytel, Li-Ying Lin, Karen J. Bowman, John W. R. Schwabe, Shaun M. Cowley, James T. Hodgkinson. Optimization of Class I Histone Deacetylase PROTACs Reveals that HDAC1/2 Degradation is Critical to Induce Apoptosis and Cell Arrest in Cancer Cells. Journal of Medicinal Chemistry, 2022; DOI: 10.1021/acs.jmedchem.1c02179 … Read more

Adaptive HEALEY ALS Platform Trial hopes to bring new treatments to patients faster

Journal Reference: Sabrina Paganoni, James D. Berry, Melanie Quintana, Eric Macklin, Benjamin R. Saville, Michelle A. Detry, Marianne Chase, Alexander V. Sherman, Hong Yu, Kristin Drake, Jinsy Andrews, Jeremy Shefner, Lori B. Chibnik, Matteo Vestrucci, Merit E. Cudkowicz, Eric Macklin, Melanie Quintana, Ben Saville, Michelle A. Detry, Lori Chibnik, Marie Abele Bind, James Chan, Matteo … Read more

Findings open the way to more precise diagnoses and treatments of Alzheimer’s disease

Journal Reference: Chae Kim, Tracy Haldiman, Sang-Gyun Kang, Lenka Hromadkova, Zhuang Zhuang Han, Wei Chen, Frances Lissemore, Alan Lerner, Rohan de Silva, Mark L. Cohen, David Westaway, Jiri G. Safar. Distinct populations of highly potent TAU seed conformers in rapidly progressing Alzheimer’s disease. Science Translational Medicine, 2022; 14 (626) DOI: 10.1126/scitranslmed.abg0253 The researchers found a … Read more

Parkinson’s protein blueprint could help fast-track new treatments

Journal Reference: Zhong Yan Gan, Sylvie Callegari, Simon A. Cobbold, Thomas R. Cotton, Michael J. Mlodzianoski, Alexander F. Schubert, Niall D. Geoghegan, Kelly L. Rogers, Andrew Leis, Grant Dewson, Alisa Glukhova, David Komander. Activation mechanism of PINK1. Nature, 2021; DOI: 10.1038/s41586-021-04340-2 The research, published in Nature, has for the first time produced a ‘live action’ … Read more

Treatments in weeks, not months: Scientists develop ambitious pandemic response plan

Journal Reference: Judith M. White, Joshua T. Schiffer, Rachel A. Bender Ignacio, Shuang Xu, Denis Kainov, Aleksandr Ianevski, Tero Aittokallio, Matthew Frieman, Gene G. Olinger, Stephen J. Polyak. Drug Combinations as a First Line of Defense against Coronaviruses and Other Emerging Viruses. mBio, 2021; 12 (6) DOI: 10.1128/mbio.03347-21 The “proactive drug development strategy” could also … Read more

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